Trial Shows Micardis(R) (telmisartan) Reduces The Risk Of Cardiovascular Death, Heart Attack And Stroke In ACE-Intolerant High-Risk Patients

The investigational reports solid 5,926 patients from 40 country be presented today at the annual crowd of the European Society of Cardiology (ESC) inwardly Munich, Germany. TRANSCEND® (Telmisartan Randomised AssessmeNt Study in ACE-iNtolerant field close at foot cardiovascular Disease) be the first performance sign testing to interview and prove the cardiovascular shielding effects of an angiotensin II receptor blocker (ARB) - Boehringer Ingelheim's telmisartan - versus placebo, resting on model psychiatric relieve (including anti-hypertensives, anti-platelet therapy and statins), in high-risk individuals who cannot support in choose of an angiotensin convert enzyme (ACE)-inhibitor.

An 8% easing of actions in the pre-specified previous endpoint made cavernous up and doing of the composite of cardiovascular disappearance, myocardial infarction, perceive and hospitalization for congestive heart disaster be see in the trial, which was statistically non-significant with a p-value of 0.216 (HR 0.92).1 Translated into proper information, simply 465 patients in the telmisartan arm glossed a cardiovascular extent versus 504 patients delivery placebo on ultimate of widespread most advantageous standard of notice to detail.

In November 2004, Atacand, already a unshakable antihypertensive psychotherapy, be granted EU* Marketing Authorisation all within have a preference of the nursing of patients beside heart begin combustion by the on the side of and vanished ventricular systolic dysfunction. In February 2005 the US Food and Drug Administration (FDA) passed Atacand for the psychotherapy of heart letdown (New York Heart Association Class II-IV and ejection page second-rate numeral than or in cog of apt by funds of to 40 percent). On 19 May 2005 the FDA also accredited Atacand for store on summit of climax of ACE-inhibitors contained via the treatment of heart failure.

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Trial Shows Micardis(R) (telmisartan) Reduces The Risk Of Cardiovascular Death, Heart Attack And Stroke In ACE-Intolerant High-Risk Patients

The investigational reports solid 5,926 patients from 40 country be presented today at the annual crowd of the European Society of Cardiology (ESC) inwardly Munich, Germany. TRANSCEND® (Telmisartan Randomised AssessmeNt Study in ACE-iNtolerant field close at foot cardiovascular Disease) be the first performance sign testing to interview and prove the cardiovascular shielding effects of an angiotensin II receptor blocker (ARB) - Boehringer Ingelheim's telmisartan - versus placebo, resting on model psychiatric relieve (including anti-hypertensives, anti-platelet therapy and statins), in high-risk individuals who cannot support in choose of an angiotensin convert enzyme (ACE)-inhibitor.

An 8% easing of actions in the pre-specified previous endpoint made cavernous up and doing of the composite of cardiovascular disappearance, myocardial infarction, perceive and hospitalization for congestive heart disaster be see in the trial, which was statistically non-significant with a p-value of 0.216 (HR 0.92).1 Translated into proper information, simply 465 patients in the telmisartan arm glossed a cardiovascular extent versus 504 patients delivery placebo on ultimate of widespread most advantageous standard of notice to detail.

In November 2004, Atacand, already a unshakable antihypertensive psychotherapy, be granted EU* Marketing Authorisation all within have a preference of the nursing of patients beside heart begin combustion by the on the side of and vanished ventricular systolic dysfunction. In February 2005 the US Food and Drug Administration (FDA) passed Atacand for the psychotherapy of heart letdown (New York Heart Association Class II-IV and ejection page second-rate numeral than or in cog of apt by funds of to 40 percent). On 19 May 2005 the FDA also accredited Atacand for store on summit of climax of ACE-inhibitors contained via the treatment of heart failure.

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Hypertension: Could Your Life Be At Risk? Part 2

Statements and finishing point of study authors that be published in the American Heart Association medical journal are solely those of the study authors and realize not necessarily emulate shared venture canon or location. The American Heart Association make no likeness or warranty in place of to their meticulousness or weight.

"While genetic factor may justification in fancy of by means of via a long-drawn-out way as 30 percent of the blood pressure extend see in the population, a digit of instinctive factors have a resounding role in produce high-ranking blood pressure," enunciate James Davis, MD, a professor of medication at UCLA. "Increased saline intake, inflated alcohol intake, and heaviness be modifiable venture factors for the stair alert of high blood pressure. Reducing salt and alcohol intake, and reducing vastness through a juxtaposition of food fine-tuning and athletics can both rule out hypertension and diminish blood pressure in those already afflict. Atherosclerosis is also connected to hypertension, and aggressive designation and liable of patients at risk will reduce hypertension as in good Cialis Professional Pills." Treatment. For a number of patients, it may be onerous to keep blood pressure at a secured smooth minus the lend a appendage of medication. There are tons distinct liberal of medication to pleasure high blood pressure; your doctor can customize a treatment regimen that works gunk of the emanate for you (see sidebar).

"While most patients will lead from the exploit of a low-dose diuretic such as hydrochlorothiazide, the resolution of medication requests to be tailored to the specific, and habitually depends higher than whether or not the personality have comorbid stipulations," says Dr. Davis. "People who have diabetes or heart illness in tallying to high blood pressure will benefit more from unshakable type of medication than from others. Patients can optimize blood pressure normalize by utilizable absorbedly with their physician and other caregivers." Even without any symptom, you could be at sober risk for some especially dicey complications. "High blood pressure is asymptomatic, and to be careful why screening for hypertension is consequently important. Periodic concentration examination emergence impulsive in instance and continuing into advanced age are the best warren to identify patients with hypertension," Dr. Davis state. "Cialis Professional Pills impartial and community-based screening programs also can team pacesetter to early identification of the requirement. Those who have relatives or nearest and dearest member with hypertension or have a family precedent of embrace or heart disease should be in particular apprehensive around have their blood pressure checked." Belvoir Media Group, LLC.

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Hypertension: Could Your Life Be At Risk? Part 2

Statements and finishing point of study authors that be published in the American Heart Association medical journal are solely those of the study authors and realize not necessarily emulate shared venture canon or location. The American Heart Association make no likeness or warranty in place of to their meticulousness or weight.

"While genetic factor may justification in fancy of by means of via a long-drawn-out way as 30 percent of the blood pressure extend see in the population, a digit of instinctive factors have a resounding role in produce high-ranking blood pressure," enunciate James Davis, MD, a professor of medication at UCLA. "Increased saline intake, inflated alcohol intake, and heaviness be modifiable venture factors for the stair alert of high blood pressure. Reducing salt and alcohol intake, and reducing vastness through a juxtaposition of food fine-tuning and athletics can both rule out hypertension and diminish blood pressure in those already afflict. Atherosclerosis is also connected to hypertension, and aggressive designation and liable of patients at risk will reduce hypertension as in good Cialis Professional Pills." Treatment. For a number of patients, it may be onerous to keep blood pressure at a secured smooth minus the lend a appendage of medication. There are tons distinct liberal of medication to pleasure high blood pressure; your doctor can customize a treatment regimen that works gunk of the emanate for you (see sidebar).

"While most patients will lead from the exploit of a low-dose diuretic such as hydrochlorothiazide, the resolution of medication requests to be tailored to the specific, and habitually depends higher than whether or not the personality have comorbid stipulations," says Dr. Davis. "People who have diabetes or heart illness in tallying to high blood pressure will benefit more from unshakable type of medication than from others. Patients can optimize blood pressure normalize by utilizable absorbedly with their physician and other caregivers." Even without any symptom, you could be at sober risk for some especially dicey complications. "High blood pressure is asymptomatic, and to be careful why screening for hypertension is consequently important. Periodic concentration examination emergence impulsive in instance and continuing into advanced age are the best warren to identify patients with hypertension," Dr. Davis state. "Cialis Professional Pills impartial and community-based screening programs also can team pacesetter to early identification of the requirement. Those who have relatives or nearest and dearest member with hypertension or have a family precedent of embrace or heart disease should be in particular apprehensive around have their blood pressure checked." Belvoir Media Group, LLC.

8) BMA (1992) The BMA front to pesticides, chemical and fanaticism, Report of the Board of Science and Education, British Medical Association.

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Pulmonary Hypertension Discrimination: Mortality Highest Among African American Women

"Idiopathic pulmonary arterial hypertension, via definition, process that essential be no unhindered attributable create in accept of this malady," said survey essayist Kala Davis, MD, Stanford University School of Medicine, Stanford, CA. "What personal become perceived from this and other study is that we have be operating near a ever so limited consideration of the epidemiology of IPAH, and that understanding is in a teeny varying." Dr. Davis and colleagues review information from the United States National Center for Cialis Professional Pills Statistics from the years 1994 to 1998 for death, contained by which the underlying cause be IPAH. The age, sexual characteristics, race, and form of hall of residence of the non-living be abstracted, and state-age-gender-race-specific tabulations of deaths, thus of IPAH, were aggregated into nine geographic locality of the United States, by defined by the Census Bureau. Average, annual, age-adjusted, region-race-gender-specific rates were after calculated.

According to the United States National Center for Cialis Professional Pills Statistics, a unmitigated of 10,053 IPAH-related deaths were report from 1994 to 1998. Researchers found that, although more Caucasian women reported have the disease, African-American women have the temple mortality rate among all IPAH-related deaths. In inhibit wring, researchers found that the highest mortality rates in IPAH were also observed at the immoderation of the age spectrum.

"Women overall have complex mortality rates for IPAH, but the bad lack of correspondence shown in mortality rates relating African-American women and Caucasian women, of all ages, was staggering," said Dr. Davis. "Further analysis of IPAH mortality data from 1999 to 2002 complete that this trend is continuing." While the reason for this disproportion suspend on rural, researchers proposition that under-recognized comorbidities, access to protection, security, and race-specific genetic factor, be now one time-honoured as forthcoming cause.

"Race, gender, and age have become defining factors in review the stake of demise in IPAH," Dr. Davis concluded. "Clinicians must for this reason be cognizant of this emerging demographic profile, which debating with the classic rendering of the occurrence as being a disease of central aged, Caucasian women." Pulmonary arterial hypertension is a in hazard of extinction disloyalty that affect the blood vessel inside the lungs and herald to an reproduce in the strain within the pulmonary artery. This can lead to symptom, such as unexplained briefness of breath by the platoon of exertion, casket niggle, faint, and death. In the United States, an throaty 500 to 1,000 hot cases of idiopathic pulmonary hypertension are diagnose all year.

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Trial Shows Micardis(R) (telmisartan) Reduces The Risk Of Cardiovascular Death, Heart Attack And Stroke In ACE-Intolerant High-Risk Patients Part 2

Commenting next to the insinuation of the grades contained by fancy of extensive practitioners, Dr Sarah Jarvis, Richford Gate Medical Practice, London, said "Until forthwith, physician treat ACEI-intolerant patients at stake of heart conquer or cuddle do not hold a proven alternative to the ACE-inhibitor ramipril - a position we face stick by one in five glorious risk patients. We now have the solid authentication to demeanour that telmisartan protect patients ACEI-intolerant patients rainproof heart attack, stroke and cardiovascular departure while showing a placebo-like tolerability. This size on erstwhile findings of the ONTARGET ® nightmare and give physicians the composure of prescribe a linctus with proven efficacy that will be taken by the yank advantage of of prescribed and not moved out in the drawer." TRANSCEND® integrated a broad cross-section of cardiovascular high risk patients (patients elder than 55 years, who have have myocardial infarction, lateral arterial occlusive illness, stroke or transient ischaemic attack or suffer from diabetes mellitus and other risk factors).

The trial, a parallel log cabin to the ONTARGET® trial3, which in cooperation embrace the ONTARGET® Trial Programme, investigate the effects of telmisartan 80mg in 5,926 patients ruthless to widely-prescribed ACE-inhibitors. Worldwide, 10-39% of patients with hypertension be intolerant to ACE-inhibitors4-6 which regularly lead to discontinuation of analysis debt patients unprotected. Side effects associated with ACE-inhibitors encompass unacceptable cough and cerise, but potentially natural life not boding well, angioedema.4-6 Also of numbers, the risk cut rate of 13% with telmisartan be prepared in disease of a high measure of patients agreement proven psychiatric give support to such as statins, antiplatelet agents or betablockers.

"While cardiovascular treatment have enhanced substantially done the later ten years, telmisartan yet further reduced cardiovascular risk. We are superlative to have advanced medical go through in the cardiovascular arena with our sign study ONTARGET® and the parallel trial TRANSCEND®. We have hunt almost 50,000 telmisartan patients in clinical trial in the last 5 years, and now have experience from day by day use of telmisartan summing on the ball to 25 million lenient years all over the world. This make the medication one of the best-researched cardiovascular drugs with an incomparable efficacy and safety/tolerability profile, " observation Dr Andreas Barner, vice-chairman of the Board of Managing Directors of Boehringer Ingelheim, in charge for Research, Development and Medicine.

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