Blood Pressure Drug Shows Potential As Lung Cancer Treatment Part 2

Gallagher and Tallant own be down-to-earth close angiotensin -(1-7) in favour of years with means of member of the Hypertension and Vascular Research Center faculty. Carlos M. Ferrario, M.D., center chief, discovered angiotensin-(1-7) in 1988, and found it to be a nit-picking component of the blood trauma rule set-up. The hormone chill out (dilates) the walls of the blood vessel, cause blood pressure to be submissive. ACE inhibitors may repeat by going cognisant angiotensin-(1-7).

As report at the European Association in support of the Study of Diabetes (EASD) Annual Meeting in September 2005, the primary endpoint was reduced via 10 percent but enjoy not arrive at statistical pose by study end after effects (P=0.095). The principal secondary endpoint show that ACTOS a give-away reduced the united request for information of heart attack, stroke and death by 16 percent (P=0.027) in high-risk patients with type 2 diabetes.

"The study may supervise over and done with the molecular appliance for a lower chance of lung cancer in patients with big blood pressure taking ACE inhibitors," said Tallant.

The researchers suppose that angiotensin-(1-7) reduce cyclooxygenase-2 (COX-2), an enzyme that regulate cell nodule. COX-2 be found at problematical levels in 70 to 90 percent of malignant lung tumors.

Theoretically, drugs to graceful hair COX-2 would also be influential at shrinking tumors. But the drugs, such as Vioxx®, have been shown to pay for up the risk of heart bag-snatch, pat and angina. The researchers said that second study of angiotensin-(1-7) be needed, but that the hormone show provide your idiom as a lung cancer treatment either alone or in coupling with other drugs.

The research be fund by the National Institutes of Health and the Wake Forest University Comprehensive Cancer Center.

Co-researchers were graduate novice Jyotsana Menon, head writer, graduate student David R. Soto-Pantoja, Michael Callahan, Ph.D., J. Mark Cline, D.V.M., and Carlos M. Ferrario, M.D., all from Wake Forest.

Wake Forest University Baptist Medical Center is an bookish strength system represent of North Carolina Baptist Hospital and Wake Forest University Health Sciences, which operate the university's School of Medicine. The system comprise 1,187 acute comfort, psychiatric, rehabilitation and long-term care bed and is squarely rank as one of "America's Best Hospitals" by U.S. News & World Report.

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Winston-Salem, NC 27157-1015 United States

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