The 'first look' at the information also found that those next to the gluey nursing strategy have a one third lesser digit unpredictability of burgeoning diabetes compare next to the elder strategy.
The 19,000 forgiving Anglo-Scandinavian Cardiac Outcomes Trial (ASCOT) had be identify a new treatment strategy all for hypertension, or righteous blood trauma, antagonistic an ancient one, spick and span to stumble on which be more at avert a range of cardiovascular measures such by way of heart harangue and tap.
In November 2004, the carrying out tests be stopped after the Steering Committee of ASCOT official the suggestion of its Data Safety Monitoring Board that the blood pressure arm of the trial should be stopped, within the red to far better grades for those patients on the new treatment.
The newer treatment strategy using the calcium trench blocker, amlodipine, and the angiotensin convert enzyme inhibitor, perindopril was compared with the older treatment strategy finish off on the beta-blocker, atenolol and the thiazide diuretic, bendroflumethiazide.
ASCOT revise co-chairmen Peter Sever from Imperial College London, UK, and Björn Dahlöf, from the Sahlgrenska University Hospital, Östra, Sweden, observation: "Although these be distinct starting results, we are positive the overall results will trace the trend we hang on see therefore far. A retrenchment of 25 percent in strokes and 15 percent in the rate of ricochet of coronary events can trademark a gargantuan incongruity to high blood pressure sufferers. Blood pressure is the commonest threat factor contributing to the intercontinental dead weight of bug, and with a projected 1.5 billion sufferers of hypertension via 2020 it is important that we move ahead more of great vastness treatment." The meticulous results of the ASCOT trial will be made going spare when all data alert to and plus the second personal patient die down by have been collected and analysed. Investigators and patients will be informed of the concluding results of ASCOT when these data become available. The results will be published in the experimental constrict.
Of completed 19,000 patients randomised to the two contrary blood pressure strategy, about 10,000 patients be also randomised to treatment with any atorvastatin or placebo in the ASCOT Lipid Lowering Arm (ASCOT-LLA). The ASCOT-LLA was stopped prematurely in October 2002, as a stirring of great benefits associated with statin burn up in the obstruction of heart attacks and strokes.
The principal financier of ASCOT is Pfizer Inc, New York. Support have also been make available by Servier Research Group, Paris and Leo Laboratories, Copenhagen.
About ASCOT Launched in 1997, the Anglo-Scandinavian Cardiac Outcomes Trial (ASCOT) is an self-directed, investigator-led study aiming to balance different treatment strategies to prevent cardiovascular disease in hypertensive patients.
It is someone conduct in over 650 unembellished dummy run or in 32 regional medical centre across the UK, Ireland and the five Nordic country, Sweden, Finland, Denmark, Norway and Iceland.
Number of patients on the ASCOT trial by manor Denmark (including Iceland) -- 1,567 Finland -- 2,382 Norway 2,226 Sweden 4,069 UK and Ireland 9,098 TOTAL 19,342 With over 19,000 patients across the UK, Ireland and Scandinavia, ASCOT is the largest European based prospective, randomised hypertension trial ever to be conducted.
It is as one in circumstance by Imperial College London (International Centre for Circulatory Health, National Heart and Lung Institute at St Marys Hospital, London) and Scandinavian Coordinating Centre (Scandinavian CRI AB), Göteborg, Sweden.
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