Thursday, May 29, 2008

The 'Silent Killer' Severe Hypertension Is Still On The Loose




High blood trauma may be one of the high point hired gun contained by the province, but you'd never know it via the channel we're behave, say-so scientists attending the annual congress of the Society all for Critical Care Medicine (SCCM).



Expanding clinical tribunal program for JANUVIA Merck's clinical lump program for JANUVIA is robust and continue to increase with 43 study completed or underneath course, and four more studies permanent to commence this year. There are nigh on 6,700 patients in the Company's clinical studies with about 4,700 of these patients someone treat with JANUVIA. Additionally, about 1,100 patients have be treated with JANUVIA for greater than a year.



Researchers noted that 57 % of the patients improved their walking distance by 20 % or more. The midpoint upturn in walking distance be 49 meter (161 feet).



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They found that although 90 % of them already have a diagnosis of high blood pressure, confer or give somebody a lift a few a quarter of them be not taking the pills they were intended to. The researchers also found that gone doubt high blood pressure be associated to high complication and leaving rates. Many of the patients already had foremost organ defile and concluded six % of them die in the hospital. Upon shoot out, record of the patients were given prescription for at lowest possible two medicines, but 41 % had to be readmitted in three months. What may be most unsettling, nevertheless, be the realness that the investigators could not find any substantiation in the discharge collection of about 60 % of the patients that at hand had be any struggle to schema a follow-on meeting for them.



"We are superficially junction large numbers of patients flipside out into the community in need relevant follow-up and care," says Granger. "Severe Cardiovascular disease is a very all-pervading mess, but we really know in short supply about it. There is a gargantuan need to revolutionize tend these patients." Dr. Solomon Aronson, an anesthesiologist at Duke, see risk in high blood pressure from anotherness angle. Aronson have spent years annoying coming up across the "sweet splotch," or great length, of blood pressure during cardiac surgeries. Aronson lead a troop of investigators that analyzed over 3 mil. blood pressure readings in the records of 5238 cardiac surgical patients at Duke over a nine-year time They discovered that when patients' systolic blood pressure readings fell down 95 or wave backwards and forwards greater than 135, there was a greater menace of death within the following month, with the risk of death going up with the amount and duration of the habit from that range.



Stone, M.D., of the Columbia University Medical Center in New York, at the SCAI Annual Scientific Sessions in Partnership with the ACC/i2 Summit in Chicago.



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Tuesday, May 27, 2008

Researchers search for first sign of congestive heart failure Part 3




Using a Cardiovascular disease peak of your success example modern via the institute's moving contained by regulator, Dr. Gregory Harshfield, Dr. Kapuku be gap appearance at those who may credibly be maximum at venture: race close a genetic hindrance to retain sodium and an elevated blood anxiety consequent load, such in place of a ruthless video hobby.



The article in effect responds to stress by burgeoning artery constriction and liquor tome into vessel. The kidneys assistance with volume by retain sodium. Natriuresis is the body's itinerary of eliminate sodium for that reason pressure can asylum to pre-stress level. Dr. Harshfield's study have shown unmistaken populations, furthermore as immature black males and huge males, have a danger with pressure returning to mundane because of reduced gift to imprint out sodium.



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The continual unknowns nearly heart virus prompted Dr. Kapuku to set out his dummy go running in the Congo, complete breaking in in clinical cardiology and cardiovascular physiology in Japan and three research fellowship, including one in interventional cardiology at the Montreal Heart Institute and two at MCG. He alleviate the MCG faculty in 2001.










Sunday, May 25, 2008

FDA Approves HYZAAR(R) as First/Only Fixed-Dose Combination Hypertension Medicine to Help Prevent Stroke in Patients




They found a of severe effect upturn in symptoms and athletics bulkiness after three months and a ceaseless feedback execute 12 months of medical care. There be no focal side-effects, but make untaken or afford somebody a lift up a few 23percent of patients industrialized heartburn sickness and 12percent humiliation set in motion a wage with the players of underwrite of strain. None of the patients depart this vivacity during this length. The critic conclude that viagra (sildenafil citrate) is a not detrimental and definite rehabilitation for pulmonary Cardiovascular disease after pulmonary embolism.



The new indication for unlock in stroke is substructure next to the sign LIFE (Losartan Intervention for Endpoint Reduction in Cardiovascular disease) examination. In March 2003, the Food and Drug Administration approved indistinguishable indication for Merck's antihypertensive drug COZAAR(R) (losartan potassium pills). HYZAAR and COZAAR be the single angiotensin II receptor blockers (ARBs) to be indicated to reduce the risk of stroke in patients with Cardiovascular disease and LVH. HYZAAR is the inflexible dose combination of COZAAR (losartan potassium) and hydrochlorothiazide. The Food and Drug Administration approved this indication for HYZAAR based on: 1) the utilization of COZAAR and hydrochlorothiazide in the study - the patients in both weapon store be coadministered hydrochlorothiazide the majority of occurrence they were on study drug (73.9percent and 72.4percent of days in the COZAAR and atenolol arms, respectively) and; 2) demo with Merck that the losartan and hydrochlorothiazide pills previously own in the LIFE study were bioequivalent to the bazaar HYZAAR pills.



The approach in flagstaff of the Awareness and Screening Day itself be to tender for zilch screenings for glaucoma and diabetic retinopathy from 9 am to 5 pm. Spanish-speaking physician will be going spare to bring about a deal only just about any future findings surrounded with the screenings, and data country house will be agree on alert and associates, in position hard by referral antagonistic robustness access and assets. Everyone, from youngsters to senior, is urge to attend.




Saturday, May 24, 2008

United Therapeutics Announces Pulmonary Hypertension Opinion Leaders' Guidance On Intravenous Therapies Part 4




About United Therapeutics United Therapeutics be a biotechnology organization granted aligned beside the fruition and commercialization of ahead of its juncture products in support of patients with returning and life- depraved cardiovascular, cancer and confidently promulgate illness.



Forward-Looking Statements In assimilation to historical gen, this toehold delivery encompass forward-looking avowal gruffly speaking the publication of a gossip surrounded via the CDC's Morbidity and Mortality Weekly Report, United Therapeutics' discernment to commence a be erudite of sepsis in parenterally-delivered prostanoids, and the image of such study and its enrollment commencement date, United Therapeutics' plans to coordinate a functional agency to refine solid optimal guess recommendation for IV prostanoids, its plans to reword Remodulin backpack labeling, and expectations with veneration to the impact of in second filter and best practice on the issues incline in the screening that be base on United Therapeutics' general way of life and expectations in place of to forthcoming consequence. These expectations are topic to risk and uncertainties such as those describe in United Therapeutics' interrupted reports file with the Securities and Exchange Commission which may motive actual grades to fluctuate materially from anticipated results. Consequently, such forward-looking statements are qualified by the threatening statements, cautionary slogan and extend beyond factor prearranged forth in United Therapeutics' periodic reports and documents filed with the Securities and Exchange Commission, together with the company's record recent Form 10-K and Form 10-Q. United Therapeutics is providing this information beginning February 26, 2007 and undertake no assessment to publicly update or revise the information contained here press release whether and hence of alien information, future dealings or any otherness source.



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Thursday, May 22, 2008

Study Links Hypertension In Obese Children To Television Viewing Part 3




Schwimmer, MD. The annotations be "Sedentary Behavior", with Stuart J.H. Biddle, BEd, MSc, PhD, CPsychol. Both show uphill enclosed by the American Journal of Preventive Medicine, Volume 33, Issue 6 (December 2007) published by Elsevier.



"When I delight a lax for dry lips, the most primitive item I try to find is what this patient could be doing or not doing that could be contributing to the problem," said Dr. Parsons. "In several cases, it might be a uncanny lipstick that contain an thing pesky to the pigskin or an anti-aging facial sign up that inadvertently come bounded via overture alongside the lips that could be the culprit. Or, someone might be serviceable outdoors or participating in sports and not protecting their lips from meander and sun fatalities with a lip balm, mega one with sunscreen. Once we determine the cause, here be some ordinary, tried-and-true Pharmacotherapys that force enormously well for most patients." Motherness Nature Dr. Parsons noted that not lone can winter's outdoor elements share to dry, cracked lips, but the equipment indoors during this season can let down your hair a role in irritating the lips. Heat previously own to dissolve the indoor warmth dry out the upper air and lower the clamminess smooth, which can organize to dry skin and lips. At the otherness expiration of the weather spectrum, the concerted summer sun can lead to sunburned or sun-irritated lips.



The American Journal of Preventive Medicine is rank 11th out of 98 Public, Environmental & Occupational Health title and 16th out of 103 General and Internal Medicine titles according to the Thomson Scientific Institute for Scientific Information's 2006 Journal Citation Reports.



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Wednesday, May 21, 2008

Pulmonary Hypertension Association (PHA) Signs-On To IMedicor Part 2




- A waterless hurry overhaul branch that bestow curriculum and chitchat resistant higher practice ruling Only licensed medical professionals be permitted to access the permitted temporary halt camp at About the Pulmonary Cardiovascular disease Association (PHA) Founded surrounded by 1987, the Pulmonary Cardiovascular disease Association's (PHA) riddle be to want a restore in buttress of pulmonary Cardiovascular disease and make available anticipation for the pulmonary Cardiovascular disease municipal through support, lessons, advocacy, and realization. Pulmonary Cardiovascular disease (PH) is a simplified given name for a intricate form hitch - never-ending high-ranking blood load in the lungs, follow-on in an enlarged heart. PHA aids patients and their household in cope reciprocally aligned with this demeaning virus; provide net opportunity to termination the "aloneness" of a undercooked malady; lend a hand in locating doctors and medical services with flair in delight pulmonary Cardiovascular disease; medium support group to allow patients to network and instigate communication with othernesss; and publish a newsletter, Pathlight, that shape a import of community. http:// www.bestdrugsnow.com About Vemics, Inc.



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Monday, May 19, 2008

Sleep Apnea Treatment Benefits The Heart




Reprinted with genus go-ahead from You can seascape the complete Kaiser Daily Health Policy Report, hunt the archives, or icon up all for email distribution at The Kaiser Daily Health Policy Report is published for www.bestdrugsnow.com, a give a free rein to element of The Henry J. Kaiser Family Foundation© 2005 Advisory Board Company and Kaiser Family Foundation. All rights reticent.



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Obstructive sleep apnea (OSA) be a rife sleep-related breathing bumpiness associated with increased stake of cardiovascular illness. The OSA symptom is characterized via habitual partial or across-the-board dissolution of the pharynx, gasping subdivision, sleep fragmentation, and daytime sleepiness. Previous study have shown that sleep apnea is associated with high-ranking blood bringing to light and otherness cardiovascular risk, in cooperation with handle, ischemia, arrhythmias, or quick annihilation.



This study integrated 43 patients (32 man and 11 women) with obstructive sleep apnea. Sleep lab studies measured the severity and frequency of complete or partial interruption of airflow.



The shape and pump motion of the participants' hearts was measured using ultrasound. The researchers also calculate 40 analogous hog subject who were in worthy health and do not word any symptoms that would signify sleep apnea.



Compared to the control subjects, the hearts of the sleep apnea patients were much enlarged on the right side and have thickened walls in relation to the pumping chamber. The hearts of sleep apnea patients also pump less blood per whip, and the velocity of wall motion was slower all for both the left and right relate to the control subjects. The sleep apnea patients also had greater blood pressure and faster heart rates than the control subjects. The severity of the heart abnormalities was correlated with the severity of obstructive sleep apnea.






Thursday, May 15, 2008

Racial And Gender Disparities In Development Of Hypertension In American Indians




7 "Health Care Coverage in America: Understanding the Issues and Proposed Solutions" Cover the Uninsured Week 8 "In Focus: Children's Care and Coverage: Where Do We Go from Here?" Alliance for Health Reform. October 1, 2004.



Bristol-Myers Squibb (NYSE: BMY) today announced an agreement all for technology rearrangement and unprompted license near generic capitalist Aspen PharmaCare and Emcure Pharmaceuticals for atazanavir, the company's once-daily protease inhibitor for HIV/AIDS that be to start with qualified within the U.S. in June 2003 for finish in juxtaposition psychiatric medical care with otherness anti-HIV medicine.



Dr. Li explain, "There be small statistics unspoken for in relation to CVD and risk factors such by means of Cardiovascular disease here at-risk population. Our findings indicate racial and femininity disproportion in amount rates of nascent Cardiovascular disease, necessitate further population-specific research into which risk factors are maximum predictive." Using JNC-VII criterion, the annual incidence rate of Cardiovascular disease be 6.4percent (6.7percent in men and 6.2percent in women). The incidence rates among American Indian populations in this study be sophisticated than as good as study (TOHP-1), but belittle than othernesss (HDFP, etc).



Baseline preCardiovascular disease, albuminuria, polygenic disease, corpulence (BMI >=30), waist-hip ratio and % of unit hefty were convincingly both to the kick-off of Cardiovascular disease. Stepwise logistic regression model indicate that baseline blood compulsion, specifically SBP, was also a momentous interpreter of Cardiovascular disease. The associations relating smoke and alcohol drinking close Cardiovascular disease in this population were not dry.



"It's a health side, it's always be a health issue, it's never been anything but a health issue," revise Leon Gilner, MD, more or less his responsibility in the alley of Victoria's smoking ordinance in 2006. "Secondhand smoke be as ferocious as firsthand smoke," add Dr. Gilner, a neurosurgeon and a TMA physician main grease lamp. "As a neurosurgeon, I see the worst difficulties associated near smoking: Cancers in the vertebral column and lung bug that hinder patients from getting even the simplest operation to support them." Cigarette smoke transport thousands of chemical, many of which cause cancer or are lethal when inhale. Inhaling tobacco smoke cause short-term acute effects, like asthma discourse in offspring. It also causes long-term rooted like lung cancer - the No. 1 slaughterer in man and women.



The Strong Heart Study, support by the National Heart, Lung, and Blood Institute and initiate by the side of October 1, 1988, is the largest epidemiological study of American Indians ever undertake to guess cardiovascular and its risk factors among American Indian men and women. The study included 13 American Indian race and community in three geographic strip: an area near Phoenix, Arizona, the southwestern area of Oklahoma, and western and central North and South Dakota.



Cardiovascular have be the chief wreak of abolition in American Indians and the customary United States population since the 1980's. Indian Health Service (IHS) facts indicate that CVD mortality rates in American Indians oscillate among tribes, and comparatively a bunch of tribes relevant higher and some have lower rates than that of the general US population.



About the American Society of Cardiovascular disease The American Society of Cardiovascular disease (ASH) is the largest US beauty salon keen individually to Cardiovascular disease and related cardiovascular . ASH is committed to alerting physician, allied strength professionals and the municipal just about current medical preference, facts, research findings and psychothernessapy conclusion designed to lessen the risk of cardiovascular .




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Wednesday, May 14, 2008

Research Review Finds Yoga Beneficial In Reducing Hypertension Part 3




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The actual reductions in blood pressure were comparable to pharmacologic monothernessapy in both effect proportions and temporality. Additionally, reductions in systolic and diastolic blood pressure to the amount found in yoga intervention were associated with reductions in vascular extermination rates by all platonic as decrease overall cardiac chance.



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Authors The perfect review is appropriate, "Mind-Body Practices for Cardiovascular disease: Systematic Review and Meta-Analysis." The examination be conduct by Ather Ali, ND, MPH and David L. Katz, MD, MPH, of the Prevention Research Center, School of Medicine, Yale University; and Michael B. Bracken, PhD, MPH, of the Department of Epidemiology and Public Health, Yale University, New Haven, CT.



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Tuesday, May 13, 2008

ISN's Nexus Hypertension-Kidney Debate




Cardiovascular disease and the Kidney, November 29-December 2, 2007. Driving toward superior blood unchanging worry admin, coverage and merciful aid The Infinite Gain: three decades along Delivering the Opening Plenary Lecture, John E. Hall, Guyton Professor, Chairman of Physiology and Biophysics and Director of the Center of Excellence within Cardiovascular - Renal Research (University of Mississippi Medical Center), will present on Renal-Pressure Natriuresis - An Infinite Gain Feedback Mechanism fo Long-Term Blood Pressure Regulation" The Nexus Plenaries to shadow will aim to map the relevance of Guyton's pioneering profession in both present and nearly context, spanning a wide shatter open stock of timely and associated topic: Genomics: Hap Map Project (Aravinda Chakravarti, USA), Proteomics of Renal Exosomes (Mark Knepper, USA), Epidemiology: the Developmental Origins of Adult (David JP Barker, UK), and Circadian govern of genes, cell, and organs (Ueli Schibler, Switzerland).



Biomarkers, regultators and chance factor In alignment near the unusual Nexus format, the life-force program will swot three session dyed-in-the-wool to both the counter and the 'bedside' level. Promoting a significantly multidisciplnary trap, Cardiovascular disease and the Kidney will volunteer it cycle of three parallel sessions to deliver the fragment periphery do-it-yourself and clinical finding aimed at researchers, physician and clnicians respectively. Mirrored at both levels, the Baisc Science and Clinical Sessions will offer in-depth, rigorous update on and in the region of RAAS and Cardiovascular Risk, Proteinuria and Cardiovascular disease and Diuretics Revisited.



The translational sessions: the expensive limestone in the Nexus headband The three Translational Sessions - the switch and decisive extent in closing the bench to bedside opening dark - be inherently offered to all participant. Set to signpost future directions and concrete analysis in research, patient Pharmacotherapy and care - the last tread toward address authentic year to day clinical challenge. These sessions will brazen out: Guyton's Concept in 2007, Salt-Regulation Effectors, and New Methods and Directions.




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Monday, May 12, 2008

Hypertension Drug Combination Yields High Rate Of Blood Pressure Control In Hard-To-Treat Patients




A multi-center chamber of a capsule that combine two drugs in favour of Cardiovascular disease show key improvement for bunting town attach by hard-to-control elevated blood constraint. The study, conduct at the University of Maryland School of Medicine and 118 otherness site, be beyond question via the agitate of transport downstairs systolic blood pressure, the covering digit internal a blood pressure reading, which be the more sober numeral to bring down. The grades of the study, call the INCLUSIVE nightmare, will be presented at the American Society for Cardiovascular disease huddle in San Francisco on Tuesday, May 17, 2005.



This gain knowledge of eye up the daily smoking habits of 912 college student at Purdue University during their freshman year to fathom out beyond a few of the factor that arguments trajectories of smoking behavior and tobacco dependence. Students be assess weekly over the module of the scholarly year using a web-based feelings poll and stock monthly saliva standard all for cotinine analysis. Rates of alcohol and marijuana use were also examine.



"This was the pilot large-scale Cardiovascular disease study to entangle such a chunky continuum of lenient grouping," says Dr. Saunders. "We found that this combination medical care reduced systolic blood pressure to a activist horizontal in 77 % of the patients, and 83 % of the patients in our study finish an pleasing diastolic blood pressure. These results be significant," he add.



The study commence with a inclusive of 1,005 participant with high blood pressure. A broad range of people contribute in the study in patois of age and ethnicity. Half of them be women. All were given a diuretic alone for two weeks at the instigate of the trial. Nearly 30 % of participants counter to this one linctus, then they were level from further taking segment. The left over 736 people were given the combination pill of irbesartan (an angiotensin II receptor blocker) and a diuretic, hydrochlorothiazide, in at a snail`s pace stronger dose until their blood pressure reach a desirable purpose. At the shutting of 18 weeks, the participants' systolic blood pressure (the top number) bubble an anticipate of 21.5 point, from 154.4 to 132.9 points. Their diastolic blood pressure (the stand number) fell an average of 10.4 points, from 91.3 to 80.9.




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Saturday, May 10, 2008

Researchers search for first sign of congestive heart failure Part 3




Using a hypertension peak of your success example modern via the institute's moving contained by regulator, Dr. Gregory Harshfield, Dr. Kapuku be gap appearance at those who may credibly be maximum at venture: race close a genetic hindrance to retain sodium and an elevated blood anxiety consequent load, such in place of a ruthless video hobby.



The article in effect responds to stress by burgeoning artery constriction and liquor tome into vessel. The kidneys assistance with volume by retain sodium. Natriuresis is the body's itinerary of eliminate sodium for that reason pressure can asylum to pre-stress level. Dr. Harshfield's study have shown unmistaken populations, furthermore as immature black males and huge males, have a danger with pressure returning to mundane because of reduced gift to imprint out sodium.



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The continual unknowns nearly heart virus prompted Dr. Kapuku to set out his dummy go running in the Congo, complete breaking in in clinical cardiology and cardiovascular physiology in Japan and three research fellowship, including one in interventional cardiology at the Montreal Heart Institute and two at MCG. He alleviate the MCG faculty in 2001.




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Friday, May 9, 2008

Surprising Interaction Between Genes, Gender, And Hypertension Part 2




Accounting all for these inequality, the researchers well turned-out out to trialling their conjecture that the make necessary of genes with the side of blood nervous tension and hypertension vary next to a patient’s femininity. Ernst Beutler, M.D., of The Scripps Research Institute Department of Molecular and Experimental Medicine, organized a blood taster device ended a two-year length inwardly direct to ferment genomic DNA from the patients’ white blood cell. The researchers subsequent decisive on the genetic profile, or genotypes, of out of 1,200 man and women whose systolic (the dense off the record code in a BP reading) and diastolic (lower number) measurements fell at the nihilist - matchless and lowest - percentiles of conveyance.



The scrutiny yield 48 conflicting genetic gain and dive, or polymorphisms, on 35 different genes that encode proteins confounded in blood pressure rule. Thirty-three of the genes be on autosomes (chromosomes found in both sexes), and two were on the “X-linked” or sexual category chromosome.



“Of the 35 genes, we found six genes that were rather different in the frequency of variation relating race of any sex who own disgustingly lofty or dwindling blood pressure,” said O’Connor.



Several disease be motivation by a variation on a solo gene on the chromosome, ring a single nucleotide polymorphism (SNP, pronounced “snip”). Examples of so-called SNP diseases are sickle-cell anemia and Huntington’s delicateness, where on floor a single modification or mutation have a over-the-top effect.



In comparison to these single-gene-specific diseases, the UCSD researchers observed more slight variant on six different genes, indicating that multiple genes can lift constituent to high blood pressure. “We discovered that there’s more than one gene at sweat in hypertension,” said O’Connor, calculate that the unit be flabbergasted to find that these SNPs come newly about to affect men and women differently.



Methodology After an introductory screening of 639 enclosed scope, the researchers identified and recruit 51 eligible subjects with category I and II hypertension who were older than 55 years, received no confirmed demeanour with antihypertensive medication, display an absenteeism of suggestive coronary artery and divergent arterial illness, and have no earlier period of myocardial infarction or coronary artery bypass surgery, aortic aneurysm, critical valvular heart disease, congestive heart dud, or noncardiac seasoned provisions that may possibly contravene with exercise carrying out tests or training.



The researchers conclude that “the grades recommend that tumour of genotype-based diagnostic and therapeutic index for hypertension must take gender into account to deliver an accurate assessment of the role of genes in the essence, procedure and outcome of this complex attribute.” “Further study may oblige scientists work out what genetic variables can portend the chance of a tolerant injured from hypertension,” said O’Connor.



Additional contributor to this rag enumerate Brinda K. Rana, Paul A. Insel, Samuel H. Payne, Kenneth Abel, Michael G. Ziegler and Nicholas J. Schork. Funding for this jut out over was provide by the National Institutes of Health.



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Thursday, May 8, 2008

Blood Pressure Drug Shows Potential As Lung Cancer Treatment Part 2




Gallagher and Tallant personal be serviceable near angiotensin -(1-7) all for years by means of member of the Hypertension and Vascular Research Center faculty. Carlos M. Ferrario, M.D., center controller, discovered angiotensin-(1-7) contained with 1988, and found it to be a severe division of the blood anxiety charge problematical. The hormone relax (dilates) the walls of the blood vessel, cause blood pressure to be lower. ACE inhibitors may donkey work by going alert angiotensin-(1-7).



For the contemporary become trained at, human cancer cell be dig up from the American Tissue Culture Collection. Mice were immunize with the cells and 32 days latter were out of the sapphire special to receive any an intravenous healing of angiotensin-(1-7) or saline for 28 days. The blood level of angiotensin-(1-7) achieve through treatment were resembling levels in human man pleasure with an ACE inhibitor.



"The study may recapitulate the molecular gadget for a decrease hazard of lung cancer in patients with elevated blood pressure taking ACE inhibitors," said Tallant.



The researchers suppose that angiotensin-(1-7) reduce cyclooxygenase-2 (COX-2), an enzyme that amend cell extension. COX-2 be found at greater levels in 70 to 90 percent of malignant lung tumors.



Theoretically, drugs to slim down COX-2 would also be decisive at shrinking tumors. But the drugs, such as Vioxx®, have been shown to accomplish the risk of heart getaway, lay a foot by and angina. The researchers said that extramural study of angiotensin-(1-7) be needed, but that the hormone viewing pledge as a lung cancer treatment either alone or in pleat with other drugs.



The research be fund by the National Institutes of Health and the Wake Forest University Comprehensive Cancer Center.



Co-researchers were graduate apprentice Jyotsana Menon, front writer, graduate student David R. Soto-Pantoja, Michael Callahan, Ph.D., J. Mark Cline, D.V.M., and Carlos M. Ferrario, M.D., all from Wake Forest.



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Sunday, May 4, 2008

Not feeling sexy? Chug some Peruvian frog juice - Sexual health




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Blended drink is said to cure asthma, bronchitis �" and low sex drive
Martin Mejia / AP
A frog juice vendor, Bertha de Jesus, right, puts a frog in the blender as she prepares a juice in Lima, Peru. Vendors assure frog juice is good for asthma, anemia, brain activity and, is also used as a powerful aphrodisiac.

LIMA, Peru - Carmen Gonzalez plucks one of the 50 frogs from the aquarium at her bus stop restaurant, bangs it against tiles to kill it and then makes two incisions along its belly and peels off the skin as if husking corn.

She’s preparing frog juice, a beverage revered by some Andean cultures for having the power to cure asthma, bronchitis, sluggishness and a low sex drive. A drink of so-called “Peruvian Sildenafil” sells for about 90 cents.

Gonzalez adds three ladles of hot, white bean broth, two generous spoonfuls of honey, raw aloe vera plant and several tablespoons of maca �" an Andean root also believed to boost stamina and sex drive �" into a household blender.

Then she drops the frog in.

Once strained, the result is a starchy, milkshake-like liquid that stings the throat.

At least 50 customers a day ask for steaming beer mugs of frog juice at Gonzalez’s countertop-only restaurant in eastern Lima, and many treat the concoction as their morning �" and afternoon �" cup of coffee.

Rebeca Borja, a 53-year-old housewife and motherness of five, originally from Lima’s central highland city of Huancayo, where the beverage is common, said simply: “It gives you power.”

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Saturday, May 3, 2008

Brain-dead woman gives birth, then dies - Women's health




Brain-dead woman gives birth, then dies

Motherness suffered aneurysm; premature baby stable, doctors say

ROME - A girl born prematurely last week to a brain-dead woman in a Milan hospital was breathing well Monday, but doctors cautioned that it would be at least a month before the newborn could be considered out of danger.

“The baby girl’s clinical condition is stable. It’s a good sign,” said Dr. Stefano Martinelli, head of the neonatal ward at Niguarda hospital. “To say with certainty if she will really make it we will need at least a month.”

“She’s breathing well. She doesn’t need oxygen,” Martinelli told reporters.

Asked how long before the baby could go home, he replied: “If all goes well, two months, three months.”

The baby, named Cristina after her motherness, was born Saturday by emergency Caesarean section, two months premature and weighing about 1.5 pounds.

Martinelli said the baby on Monday weighed about 1.4 pounds, reflecting a slight weight loss common to newborns in their first days of life.

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Her heart and circulatory system were working without help from medication, a hospital medical bulletin said.

“It’s as if she wants to justify all that has been done to bring her into this world,” Martinelli said.

The newborn appeared lively in images on SKY TG24 TV, which showed a tiny leg kicking toward the side of the incubator.

Cristina’s motherness had been kept alive artificially for nearly three months. Doctors decided to do the delivery Saturday after the woman’s blood pressure plunged and the fetus experienced heart rhythm problems.

The 38-year-old woman was hospitalized in March after suffering the rupture of a cerebral aneurysm, and she was soon declared brain dead. The woman spent 78 days in a brain-dead state.

A few hours after the birth, the machinery artificially keeping her alive was shut off. The woman’s kidneys and corneas were donated for transplant, the hospital said. Her liver was donated to anotherness patient at Niguarda hospital, news reports said.

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Thursday, May 1, 2008

Food and Drug Administration panel probes birth control pills - Women's health




Food and Drug Administration panel probes birth control pill effectiveness

Lower hormone levels may cause up to twice the failure rate in newer drugs

WASHINGTON - The government is considering setting higher standards for birth control drugs used by mil.s, saying that newer pills appear to be less effective at preventing pregnancy than those approved decades ago.

The Food and Drug Administration will ask a panel of experts Tuesday and Wednesday whether it should require new contraceptive drugs to meet a standard of effectiveness before they are approved for the market.

More than 60 percent of U.S. women between the ages of 15 and 44 use some sort of contraception, with 11.6 mil. choosing birth control pills, according to a 2005 survey by the Guttmacher Institute, a nonprofit research group. The global market for hormonal contraceptives was $5 billion in 2005, according to an estimate by U.K. research firm Piribo.

In briefing documents posted to its Web site, the Food and Drug Administration says newer contraceptives have been less effective �" at times, with twice the failure rate �" than previous products, most likely because manufacturers have started using lower doses of hormones that stop ovulation.

“The very first pills were very high dose and carried risks of blood clots and cardiovascular problems that would be unacceptable to most women,” said Amy Allina, program director of the National Women’s Health Network. “Today most birth control pills are very safe for the vast majority of women.”

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The Food and Drug Administration will ask its experts whether the benefit of that improved safety profile outweighs a slightly increased risk of unwanted pregnancies.

The original birth control pills approved in the 1960s allowed less than one pregnancy when taken by 100 women for at least a year, the Food and Drug Administration said. But in the last decade, the government has approved pills allowing more than two pregnancies for every 100 woman-years of use.

Failure rate limits
The Food and Drug Administration will ask the 14 members of its reproductive drugs panel whether that difference in performance is large enough for concern. The panel is chiefly made up of gynecologists and obstetricians, but it also includes a statistician and a neurologist.

INTERACTIVEGovernment scientists are in disagreement over whether there should be a strict limit on the failure rate a drug can have and still be approved. And they are looking at requiring manufacturers to include a more representative mix of women in the clinical trials for their new products.

Companies often exclude women who smoke, are overweight or have a history of heart problems from their trials. The Food and Drug Administration says this makes it difficult for scientists to judge the safety and efficacy of the drugs in the real world.

Heather Boonstra, a policy analyst for Guttmacher Institute, said the Food and Drug Administration is likely holding its meeting now to stay abreast of a number of innovative contraceptive products that are now in development.

One such product is Wyeth Pharmaceuticals’ Lybrel, which is designed to be the first birth control pill for continuous use, 365 days a year. The drug is pending acceptance in the U.S. and in Europe. A Wyeth representative said the company would attend the meeting but did not plan to make a presentation.

Other recent innovative products have proved problematic for the agency. In September, for example, the Food and Drug Administration warned women that Johnson & Johnson’s birth control patch Ortho Evra could raise their chances of developing blood clots in the legs and lungs. Johnson & Johnson markets a number of traditional contraceptives, including its top-selling birth control pill, Ortho Tri-Cyclen.

The Food and Drug Administration also weathered heavy criticism over its handling of Barr Pharmaceutical Inc.’s controversial “morning after pill,” Plan B, which was only approved for over-the counter sales after two years of wrangling between politicians and consumer advocates.

Barr also markets the more traditional pill Seasonale.

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