Blood Pressure Drug Shows Potential As Lung Cancer Treatment Part 2

Gallagher and Tallant personal be serviceable near angiotensin -(1-7) all for years by means of member of the Hypertension and Vascular Research Center faculty. Carlos M. Ferrario, M.D., center controller, discovered angiotensin-(1-7) contained with 1988, and found it to be a severe division of the blood anxiety charge problematical. The hormone relax (dilates) the walls of the blood vessel, cause blood pressure to be lower. ACE inhibitors may donkey work by going alert angiotensin-(1-7).

For the contemporary become trained at, human cancer cell be dig up from the American Tissue Culture Collection. Mice were immunize with the cells and 32 days latter were out of the sapphire special to receive any an intravenous healing of angiotensin-(1-7) or saline for 28 days. The blood level of angiotensin-(1-7) achieve through treatment were resembling levels in human man pleasure with an ACE inhibitor.

"The study may recapitulate the molecular gadget for a decrease hazard of lung cancer in patients with elevated blood pressure taking ACE inhibitors," said Tallant.

The researchers suppose that angiotensin-(1-7) reduce cyclooxygenase-2 (COX-2), an enzyme that amend cell extension. COX-2 be found at greater levels in 70 to 90 percent of malignant lung tumors.

Theoretically, drugs to slim down COX-2 would also be decisive at shrinking tumors. But the drugs, such as Vioxx®, have been shown to accomplish the risk of heart getaway, lay a foot by and angina. The researchers said that extramural study of angiotensin-(1-7) be needed, but that the hormone viewing pledge as a lung cancer treatment either alone or in pleat with other drugs.

The research be fund by the National Institutes of Health and the Wake Forest University Comprehensive Cancer Center.

Co-researchers were graduate apprentice Jyotsana Menon, front writer, graduate student David R. Soto-Pantoja, Michael Callahan, Ph.D., J. Mark Cline, D.V.M., and Carlos M. Ferrario, M.D., all from Wake Forest.

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