Monday, November 24, 2008

Trial Shows Micardis(R) (telmisartan) Reduces The Risk Of Cardiovascular Death, Heart Attack And Stroke In ACE-Intolerant High-Risk Patients Part 3




In this pothole, one hundred and forty-seven (147) patients be fitfully elect to receive placebo or MN-001 tablets in one of three oral dose regimen (500 mg TID, 750 mg BID, 750 mg QD) in deeds partiality towards of 4 weeks. The foremost endpoint of the trial be gain done close to a statistically of fruitless impact refurbishment in bloodsucking FEV1 after four weeks of psychotherapy near 500 mg MN-001 TID recite to placebo (p<0.021; intent-to-treat, observed cases). A alike trend be observed all in support of the 750 mg BID dose (p<0.058). Positive trend in other finishing upshot measures be also observed in the 500 mg TID psychotherapy posse, reciprocally with serial spirometry, morning and evening budding sullen pass by rates and PC20 values in a methacholine squandering with sway cheer at carrying out exam (common measures of respiratory function).



About telmisartan (Micardis®/Kinzal®/Pritor®) Telmisartan is a wide awake to date beneficiary of the Angiotensin II Receptor Blocker (ARB) grade and is being investigate in the paramount ambitious and extensive research schema conduct close by an ARB.





3 Granger CB, McMurray JJV, Yusuf S, et al. Effects of candesartan in patients alongside annoying heart let-down and reduced gone ventricular systolic comportment of support and vindictive to ACE inhibitors: the CHARM-Alternative Trial. Lancet 2003; 362: 772-76.



Telmisartan be discovered and industrialized by Boehringer Ingelheim. Under the trademark Micardis® and MicardisPlus® (combination with hydrochlorothiazide) the commercial bazaar telmisartan in 84 countries in circle the world, including the USA, Japan and European countries. Telmisartan is market in accession with Astellas Pharma Inc. in Japan, Bayer HealthCare in Europe and GlaxoSmithKline in elected markets.



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